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Advantages of MonoLex™
aptamers:
-
chemical synthesis
of the combinatory library,
-
low target quantity
required for isolation (see also requirements),
-
in-vitro selection process
with a proprietary one-step approach,
-
no structural bias
caused by polymerase selectivity during repeated selection cycles,
- selection of
high affinity aptamer pools with
different levels of high affinity (
polyclonal aptamers),
-
each pool contains
many target specific aptamers,
-
narrow range of affinity level
in each aptamer pool,
-
production and modification by
enzymatic amplification
for immediate use,
-
identification of aptamer molecules by cloning and sequencing
on demand (
monoclonal aptamers),
-
fast availability of aptamers for drug validation and quantification after
high throughput drug identification
.
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